Brock E. Polnaszek, MD; Jessica Chen, MD; Rodolfo Fernandez-Criado, MD, MPH; Anna Palatnik, MD; Susan Cohen, MD; Methodius G. Tuuli, MD, MBA, MPH; Adam K. Lewkowitz, MD, MPHS
WMJ. 2025;124(3):274-276.
ABSTRACT
Background: This pre-specified analysis of a randomized controlled trial compared electronic fetal monitoring patterns among participants with and without amnioinfusion.
Methods: Data from the parent randomized trial included 26 term singleton nulliparous participants who developed risk factors for fetal neurologic injury. For this secondary analysis, the primary outcome was total deceleration area—a pattern predictive of neonatal acidemia and morbidity. Secondary outcomes included electronic fetal monitoring patterns (eg, variability).
Results: There were no differences in total deceleration area between the no amnioinfusion group and the amnioinfusion group (28 550 [8800–57 400] mm² [IQR] vs 31 500 [21 700–47 785] mm² [IQR], respectively; P = .84). Specific secondary outcomes differed by amnioinfusion.
Conclusions: These results highlight the need for prospective data to identify the optimal amnioinfusion administration technique that reduces morbidity.