University of Wisconsin–Madison Medical College of Wisconsin

The Perceptions of Infertility Patients Regarding the COVID-19 Vaccine: A Mixed Methods Analysis of Patient Readiness

David Eggert, DO; Amy Pan, PhD; Cassandre R. Krier; Kate Schoyer, MD; Kristina Kaljo, PhD; Stephanie Gunderson, MD

WMJ. 2024;123(6):528-532.

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ABSTRACT

Introduction: We sought to elucidate infertile patient perceptions regarding the novel COVID-19 vaccine as it pertained to fertility treatments and future pregnancies.

Methods: Patients visiting the Froedtert North Hills Health Center for Fertility and Reproductive Medicine in Menomonee Falls, Wisconsin from July 1, 2020, through June 6, 2021, were invited to participate in a mixed methods survey assessing infertile patient perceptions regarding clinic closures, delays in treatment, and the COVID-19 vaccine. The main outcomes measured were readiness to receive the COVID-19 vaccine in the setting of trying to conceive.

Results: There were 760 surveys sent with a total of 192 completed surveys (response rate = 25.3%). Respondents who reported having a college or post graduate education were more likely to consider the COVID-19 vaccine when it became available to them (P < 0.001). When participants’ responses were stratified by the number of previous completed fertility treatments (either embryo transfers or intrauterine inseminations), there was a statistically significant trend of increasing willingness to receive the COVID-19 vaccine as the number of completed fertility treatments increased even when considering a pregnancy or while breastfeeding (P = 0.004 and P = 0.001, respectively). Qualitative themes included participants’ fear of the unknown due to existing perceptions, beliefs, and mistrust; interpretations of medical knowledge, and desire for provider guidance and mindful communication.

Conclusions: This study suggests that despite identified hesitancy of the COVID-19 vaccine, patients with higher levels of education and those who completed an increasing number of infertility treatments were more willing to consider the COVID-19 vaccine.


Author Affiliations: Department of Obstetrics and Gynecology, Medical College of Wisconsin (MCW), Milwaukee, Wisconsin (Eggert, Schover, Kaljo, Gunderson); Department of Pediatrics, Qualitative Health Sciences, MCW, Milwaukee, Wisconsin (Pan); MCW, Milwaukee, Wisconsin (Krier).
Corresponding Author: Stephanie Gunderson, MD, 8701 W Watertown Plank Rd, Milwaukee, WI 53226; phone 414.805.6600; email sgunderson@mcw.edu; ORCID ID 0000-0003-2703-5169
Funding/Support: None declared.
Financial Disclosures: None declared.
Acknowledgements: The authors would like to acknowledge and thank Pippa Simpson, PhD, for her work on the statistical analysis.
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