University of Wisconsin–Madison Medical College of Wisconsin

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Pharmacotherapy Update

Journavx (suzetrigine)

On January 30, 2025, the US Food and Drug Administration (FDA) approved Journavx (suzetrigine), a non-opioid analgesic, for the management of moderate-severe acute pain. Journavx is the first drug to be approved that targets the voltage-gated sodium channel NaV1.8. This novel target marks a new therapeutic class of non-opioid analgesics.

Published online March 31, 2026.

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