University of Wisconsin–Madison Medical College of Wisconsin

Transaminase Elevation in Nutritional Infantile Failure to Thrive

Kristen A. Marten, DO; Nicole E. St. Clair, MD; Daniel M. O’Connell, MD; Daniel J. Sklansky, MD

WMJ. 2022;121(1):61-63

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Introduction: Laboratory investigations pursued for infants with failure to thrive (FTT) often show mild transaminase elevations, the incidence and significance of which are unknown.

Methods: This retrospective chart review included infants diagnosed with simple nutritional FTT at a single academic tertiary care system. Comparisons of diagnostic studies and outcomes between children with and without transaminase elevation were performed using chi-square and Wilcoxon rank sum tests.

Results: None of the infants with abnormal transaminases required additional follow-up or developed alternative diagnoses in the following year.

Discussion: Transaminase elevation may be common in infants with FTT and may not warrant further investigation if the history indicates an isolated etiology of insufficient nutrition.

Author Affiliations: Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin (Marten, St. Clair, O’Connell, Sklansky).
Corresponding Author: Kristen A Marten, DO, UW Health West Clinic, 451 Junction Rd, Madison, WI 53717, phone 608.265.7740; email
Acknowledgement: This research was presented as a poster at the regional Academic Pediatric Association meeting and Pediatric Academic Society in Spring 2019 and at the AAP National Conference and Exhibition in Fall 2019. All authors approve of and have agreed to submit the manuscript to this journal.
Funding/Support: None declared.
Financial Disclosures: None declared.
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