Kristen A. Marten, DO; Nicole E. St. Clair, MD; Daniel M. O’Connell, MD; Daniel J. Sklansky, MD
Introduction: Laboratory investigations pursued for infants with failure to thrive (FTT) often show mild transaminase elevations, the incidence and significance of which are unknown.
Methods: This retrospective chart review included infants diagnosed with simple nutritional FTT at a single academic tertiary care system. Comparisons of diagnostic studies and outcomes between children with and without transaminase elevation were performed using chi-square and Wilcoxon rank sum tests.
Results: None of the infants with abnormal transaminases required additional follow-up or developed alternative diagnoses in the following year.
Discussion: Transaminase elevation may be common in infants with FTT and may not warrant further investigation if the history indicates an isolated etiology of insufficient nutrition.