University of Wisconsin–Madison Medical College of Wisconsin

Hereditary Angioedema: A Review

Heidi Zafra, MD

WMJ. 2022;121(1):48-53

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Hereditary angioedema (HAE) is a rare and disabling disorder wherein there is excessive bradykinin production, with subsequent increased vascular permeability in the superficial tissues and gastrointestinal and respiratory mucosa. This article serves as a review of the pathogenesis of the disease, as well as an update of the evidence-based new treatment recommendations to help clinicians with the diagnosis and management of HAE.

Author Affiliations: Division of Allergy/Clinical Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Corresponding Author: Heidi Zafra MD, 9000 W Wisconsin Ave, Suite 440, Milwaukee, WI 53226; email; ORCID ID 0000-0001-5410-1462.
Funding/Support: None declared.
Financial Disclosures: None declared.
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