University of Wisconsin–Madison Medical College of Wisconsin

A Case of Doxycycline-Induced Pancreatitis

Jeremiah Kakes, MD; William E. Cayley, Jr., MD, MDiv; Justin Sporleder, MD

WMJ. 2024;123(1):43-47.

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Introduction: Acute pancreatitis is a common cause of hospitalizations in the United States, causing approximately 230 000 to 275 000 annual admissions We present the case of a patient with acute pancreatitis likely due to doxycycline.

Case Presentation: A 64-year-old male was admitted after developing acute epigastric pain radiating to his back, a lipase of 6611 (units/L), and a computed tomography scan showing moderate peripancreatic inflammation. He had no recent alcohol use, his gallbladder was surgically absent, and he had no gallbladder pathology on evaluation; however, he had been started on doxycycline 10 days prior. While hospitalized, he was treated with pain medications, fluids, and antibiotics for aspiration pneumonia. His acute symptoms resolved, except for minor intermittent abdominal pain 2 months after discharge.

Discussion: Doxycycline-induced pancreatitis has been reported within 3 to 17 days of medication initiation. Given the temporal correlation and lack of other inciting etiologies, we determined the most likely etiology was doxycycline.

Conclusions: Further study is needed to understand the pathophysiology and incidence of doxycycline-induced pancreatitis.

Author Affiliations: Wisconsin North Central GME Consortium (WiNC), Prevea Family Medicine Residency, Eau Claire, Wisconsin (Kakes, Sporleder); University of Wisconsin School of Medicine and Public Health, Madison, Wis (Cayley); Prevea Family Medicine Residency, Eau Claire, Wis (Cayley).
Corresponding Author: Jeremiah Kakes, MD, Prevea Health, 617 W Clairemont Ave, Eau Claire, WI 54701; phone 715.839.5175; email; ORCID ID 0000-0002-6463-3814
Funding/Support: None declared.
Financial Disclosures: None declared.
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