University of Wisconsin–Madison Medical College of Wisconsin

A Unique Case of Coexisting Anaplasmosis and Blastomycosis

Samira Samant, MD; James McCarthy, MD

WMJ. 2024;123(2):141-143

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Introduction: In presenting this case of tick-borne illness in a patient with known disseminated blastomycosis, we aim to discuss the clinical reasoning and decision-making process when treating a septic presentation in a complex patient with multiple exposures and risk factors, from identifying and addressing the most devastating differentials to selecting appropriate empiric anti-infective regimens.

Case Presentation: We present the case of a 60-year-old male with a medical history of diastolic heart failure, cirrhosis, sarcoidosis, hypertension, splenectomy, and recently diagnosed disseminated blastomycosis, who developed sepsis following a recent tick exposure.

Discussion: While a review of the literature revealed a paucity of cases of coexisting fungal and tick-borne illness, each is independently well-studied. Several reported commonalities exist between Blastomyces and Anaplasma, including endemic regions and at-risk populations.

Author Affiliations: Medical College of Wisconsin, Milwaukee, Wisconsin (Samant, McCarthy).
Corresponding Author: Samira Samant, MD; email; ORCID ID 0009-0006-2304-2715
Funding/Support: None declared.
Financial Disclosures: None declared.
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