University of Wisconsin–Madison Medical College of Wisconsin

Distal Tibia and Foot Involvement in a Patient With Waldenstrom’s Macroglobulinemia

Priyanka, MD; Richard Mercier, MD; Rahul Raiker, BS; Bindu Potugari, MD

WMJ. 2019;118(1):88-91.

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Bone lesions are a rare presentation in Waldenstrom’s macroglobulinemia patients. Although lytic bone lesions and generalized osteoporosis have been described variably in literature on Waldenstrom’s macroglobulinemia patients, distal long bone and foot involvement has not been described to our knowledge. We report a patient with Waldenstrom’s macroglobulinemia with IgM monoclonal spike, plasmacytic infiltration of bone marrow, and symptoms of foot pain, and found to have distal tibia and foot involvement. The symptoms of bone lesions in our patient were significantly improved with radiation treatment. The possibility of distal involvement of long bones in a clinically relevant presentation should be kept in mind in these patients.

Author Affiliations: Department of Internal Medicine, Marshfield Clinic, Marshfield, Wis (Priyanka, Potugari); Department of Hemato-oncology, Marshfield Clinic, Marshfield, Wis (Mercier); Department of Internal Medicine, West Virginia University, Morgantown, West Virginia (Raiker).
Corresponding Author: Priyanka, MD, Marshfield Clinic, Marshfield, WI, 54449; phone 715.897.0270; email
Funding/Support: None declared.
Financial Disclosures: None declared.
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