Augusto Dextre-Espinoza, BS; Sofia Ildefonso-Najarro, MSc; Fiorella Beatriz Gonzales Chiroque, BS; Eric Edwin Edinson Vasquez Garcia, BS; Jenyfer María Fuentes-Mendoza; Luis Concepción-Urteaga, PhD; Marcio Concepción-Zavaleta, MSc
WMJ. 2026;125(2):305-308. Published June 2, 2026.
ABSTRACT
Introduction: Granular cell tumors of the neurohypophysis are rare, benign neoplasms originating from pituicytes that often pose diagnostic challenges due to their resemblance to other sellar lesions.
Case Presentation: We report the case of a 26-year-old man with a 2-year history of headache, polyuria, and hypopituitarism. Magnetic resonance imaging revealed a 21 × 23×30 mm suprasellar mass compressing the optic chiasm and hypothalamus. Hormonal evaluation showed hypogonadotropic hypogonadism, central hypothyroidism, and arginine vasopressin deficiency. The patient underwent partial tumor resection. Histopathology confirmed a grade I granular cell tumor, positive for thyroid transcription factor 1, S100, and vimentin.
Discussion: Granular cell tumors are slow-growing lesions with nonspecific clinical and radiologic features. Diagnosis relies on histologic and immunohistochemical findings. Complete resection is often limited by tumor vascularity and proximity to vital structures.
Conclusions: Granular cell tumors should be considered in the differential diagnosis of suprasellar tumors. Early recognition and multidisciplinary management may improve patient outcomes.